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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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Mosapride citrate is an orally active gastroenterokinetic compound, acting as a 5HT4 agonist and a CYP inducer. It demonstrates a concentration-dependent inhibitory effect on Kv4.3 with an IC50 value of 15.2 μM. This compound is suitable for use in the study of gastrointestinal diseases.
Acts as a 5HT4 agonist
Functions as a CYP inducer
Exhibits concentration-dependent inhibitory effect on Kv4.3 with an IC50 of 15.2 μM
Promotes gastric emptying
Relieves NSAID-induced ulcers by activating the 5-HT4 receptor
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Fmoc-NH-PEG6-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This compound leverages the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
Cleavable ADC linker
PEG-based PROTAC linker
Utilized in antibody-drug conjugate (ADC) synthesis
Used in PROTAC synthesis
Leverages intracellular ubiquitin-proteasome system
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Mosapride citrate is an orally active gastroenterokinetic compound. It acts as a 5HT4 agonist and a CYP inducer. It exhibits a concentration-dependent inhibitory effect on Kv4.3, with an IC50 value of 15.2 μM. Mosapride citrate is used in the study of gastrointestinal diseases.
Orally active gastroenterokinetic compound
5HT4 agonist
CYP inducer
Inhibitory effect on Kv4.3
Useful for studying gastrointestinal diseases
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(E/Z)-Zotiraciclib citrate is a potent inhibitor targeting CDK2, JAK2, and FLT3. This compound is supplied as a solid, appearing off-white to light yellow, and is intended for research use only.
Potent CDK2, JAK2, and FLT3 inhibitor
High purity: 99.83%
Molecular weight: 564.59
Store at 4°C, sealed, away from moisture
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Gefapixant citrate is a P2X3 receptor antagonist provided as a concentrated solution for laboratory research. The reagent is supplied at 10 mM in DMSO (1 mL) and is intended for in vitro pharmacology and biochemical studies, with analytical documentation available from the manufacturer.
Ready-to-use 10 mM solution in DMSO, 1 mL.
High purity (99.2%) suitable for research applications.
Supports in vitro P2X3 receptor pharmacology and biochemical assays.
Comes with data sheet, certificate of analysis, and safety data sheet.
For research use only; not for human or diagnostic use.
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TCEP (Tris (2-Carboxyethyl) phosphine Hydrochloride) is an odorless reducing agent suitable for protein applications and in the preparation for electrophoresis. TCEP is water soluble, is stable in a variety of solutions and is particularly useful in the labeling of cysteine residues with maleimides, preventing the cysteines from forming disulfide bonds.
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Also available in 10 mg, 25 mg, 50 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity. Purity ≥95%
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Pacritinib (SB1518) citrate is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). It also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). This compound can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF).
Potent inhibitor of wild-type JAK2 (IC50=23 nM)
Potent inhibitor of JAK2V617F mutant (IC50=19 nM)
Inhibits FLT3 (IC50=22 nM)
Inhibits FLT3D835Y mutant (IC50=6 nM)
Used for research in acute myeloid leukemia (AML) and myelofibrosis (MF)
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Dihydrofluorescein diacetate (also called fluorescin diacetate) is hydrolyzed by cellular esterases to dihydrofluorescein (also called fluorescin) and is then oxidized to fluorescein primarily by H2O2.
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Citrate synthase catalyzes the initial reaction of the citric acid cycle, condensing acetyl-CoA and oxaloacetate to form citrate. This enzyme is primarily localized within the mitochondrial matrix of eukaryotic cells. Each unit of the enzyme is defined by its ability to form 1.0 μmole of citrate from oxalacetate and acetyl CoA per minute at pH 8.0 at 37°C.
Catalyzes key reaction in citric acid cycle
Localized in mitochondrial matrix
Biochemical reagent
Metabolic enzyme/protease
Endogenous metabolite
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